TOKAI UNIVERSITY Researchers Guide 2020

We are conducting basic research for the development of novel therapeutic methods for hematopoietic malignancies with a dierent approach from conventional one. Main projects are: Signicance of the microenvironment in Epstein Barr virus (EBV) -related lymphomaSignicance of exosomes in EBV-related lymphoma and HBV hepatitisChanges in lipoquality of phospholipids in cancer and its biological signicanceFunction of non-code RNA in hematopoiesis, hematopoietic diseases, and hepatitisPDL1 inducers and mechanism of action in autoimmune diseasesResearchAreasMedicine, dentistry, and pharmacyKeyword■Hematological malignancy■Extracellular vesicle■Non-coding RNA■VirusRelatedresearchSDGInvestigation of pathogenesis of hematological malignancy from the points of view such as extracellular vesicles, nonーcoding RNA, and virus biologyProfessorAi KotaniUndergraduate School of MedicineFaculty of Medicine Basic Clinical Science and Public Health CourseI have been engaged in the research of surgical and molecular pathology of pancreatic neoplasms. In recent years, my research has focused on the expression and role of nectin and necl, which are cell adhesion molecules. I revealed the following results: low nectin-3 and necl-4 expression is associated with shorter overall survival in pancreatic ductal adenocarcinoma (Surg Today. 2015;45:487-94, J Clin Pathol. 2017;70:619-24) and low nectin-3 expression is associated with a shorter disease-free survival in pancreatic neuroendocrine tumors (Pathol Int. 2020;70:84-91). Currently, I am advancing research on microRNAs related to nectin and necl.ResearchAreasMedicine, dentistry, and pharmacyKeyword■Pancreas■Neoplasm■Pathology■miRNA■BiomarkerRelatedresearchSDGAnalysis of nectin/necl and miRNA expression in pancreatic neoplasmsAssociate ProfessorKenichi HirabayashiUndergraduate School of MedicineFaculty of Medicine Basic Clinical Science and Public Health CourseSocial factors such as climate change, population density, and human migration had greatly contributed to the recent epidemics of zoonotic infection including novel inuenza, re-emerging infectious diseases and imported infectious diseases. I showed that environmental control measures such as indoor air ventilation and ultraviolet germicidal irradiation in upper room would be eective in reducing tuberculosis infection risk by the mathematical modeling. And I also showed that the infection risks of vector-borne diseases in Japan were estimated and that urban heat island effect would increase infection risks. Currently, I have been estimating the infection risk of COVID-19 through the different modes of transmission with using the mathematical modeling.ResearchAreasMedicine, dentistry, and pharmacyKeyword□Infectious disease□Mathematical modeling□Zoonotic infectionRelatedresearchSDGResearch on systems thinking in combating infectious diseases and health care systemsAssociate ProfessorHiroyuki FuruyaUndergraduate School of MedicineFaculty of Medicine Basic Clinical Science and Public Health Course111

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