TOKAI UNIVERSITY Researchers Guide 2020

When kidney function declines, several abnormalities of bone metabolism develop. Among them, uremic toxins accumulated in the serum of patients with kidney disease are the main targets of our research team.ResearchAreasMedicine, dentistry, and pharmacyKeyword■Kidney■Parathyroid■Uremic toxins■Bone■PhosphateRelatedresearchSDGUremic toxins and bone metabolism in kidney diseaaesProfessorMasafumi FukagawaUndergraduate School of MedicineFaculty of Medicine Medical Science CourseThe overall theme of our lab is disordered mineral metabolism in kidney disease, with special focus on the role of parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and Klotho. While we have long been interested in the pathogenesis, treatment, and outcome of secondary hyperparathyroidism in patients with kidney failure and the role of FGF23 and Klotho in this disorder, our current interests extend to the non-traditional action of PTH and the role of Klotho in the regulation of FGF23 synthesis by osteocytes.ResearchAreasMedicine, dentistry, and pharmacyKeyword■CKD-MBD■Secondary hyperparathyroidism■Hyperphosphatemia■Osteoporosis■FGF23-Klotho axisRelatedresearchSDGThe role of parathyroid hormone, broblast growth factor 23, and Klotho in disordered mineral metabolism in kidney diseaseAssociate ProfessorHirotaka KomabaUndergraduate School of MedicineFaculty of Medicine Medical Science CourseI am interested in understanding how the gut microbiota and host immunity interact in inammatory bowel disease. I have focused on the mechanism how pathobionts promote chronic intestinal inflammation. Especially, we investigated the association between Adherent-invasive Escherichia coli (AIEC) and intestinal brosis. Furthermore, we are investigating how acquired immunity works against pathobionts. These works will provide new therapeutic option in inammatory bowel disease. ResearchAreasMedicine, dentistry, and pharmacyKeyword■Inammatory bowel disease■Gut microbiota■Mucosal immunologyRelatedresearchSDGUnderstanding pathobionts and host immunity in inammatory bowel diseaseAssistant ProfessorJin ImaiUndergraduate School of MedicineFaculty of Medicine Medical Science Course114

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