TOKAI UNIVERSITY Researchers Guide 2020

120/148

We have proposed a two-tier system in grouping cervical adenocarcinoma for survival discrimination using the Japan Society of Gynecologic Oncology tumor registry database from 2001 to 2015 (n = 86,754). Adenocarcinoma subtypes were grouped as type 1 (endocervical usual type and endometrioid) or type 2 (serous, clear, mucinous, and not otherwise specied) compared with that of squamous tumors. We found that the survival of cervical adenocarcinoma varies largely across the histological subtypes, and Now, we are exploring the molecular biology cervical adenocarcinoma based on the histological subtypes.ResearchAreasMedicine, dentistry, and pharmacyKeyword■Gynecologic oncology■Cervical cancer■Endometrial cancer■Ovarian cancerRelatedresearchSDGProposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine CervixAssistant ProfessorHiroko MachidaUndergraduate School of MedicineFaculty of Medicine Specialized Clinical Science CourseI am an analytical toxicologist, and very much interested in forensic toxicology. My research theme is "hair analysis for clinical and forensic toxicology.” Hair analysis for abused drugs may be a useful technique to conventional drug testing in toxicology such as blood and urine. Segmental hair analysis provides previous information on drug intake such as abused drugs and medicines. Hair samples are easy to collect without invasive procedures. Since the concentrations in hair are very low, liquid chromatography_tandem mass spectrometry system is more suitable.ResearchAreasMedicine, dentistry, and pharmacyKeyword■Forensic Toxicology■Clinical Toxicology■Hair AnalysisRelatedresearchSDGHair analysis for clinical and forensic toxicologyAssociate ProfessorTakeshi SaitoUndergraduate School of MedicineFaculty of Medicine General and Acute Medicine CourseAfter discovery of PEG10 as the first mammalian-specific gene from an LTR retrotransposon, we demonstrated that Peg10 plays an essential role in mammalian viviparous reproduction system via its placental function. We also demonstrated that Peg11/Rtl1 derived from the same LTR retrotransposon is also an essential placental gene. We assume that these genes have been deeply involved in mammalian evolution as newly acquired genes together with nine additional genes from the same LTR retrotransposon. We named these genes sushi-ichi related homologue (SIRH) genes (now formally called retrotranposon Gag-like (RTL) genes). We have been conducting systematic research on all SIRH genes using their knockout mice. ResearchAreas Biological sciencesKeyword■Mammalian-specic gene■LTR retrotransposon■Viviparity■Placenta■Genome imprintingRelatedresearchSDGDiscovery of mammalian-specic domesticated genes and elucidation of their biological functionsProfessorTomoko IshinoUndergraduate School of MedicineFaculty of Nursing118