{"id":1249,"date":"2017-07-13T13:35:18","date_gmt":"2017-07-13T04:35:18","guid":{"rendered":"urn:uuid:67324a78-ab72-4090-a231-5987582945a5"},"modified":"2021-05-21T06:32:07","modified_gmt":"2021-05-20T21:32:07","slug":"genome_biology","status":"publish","type":"post","link":"https:\/\/www.u-tokai.ac.jp\/ud-medicine\/news\/1249\/","title":{"rendered":"\u533b\u5b66\u90e8\u30fb\u5927\u585a\u6b63\u4eba\u51c6\u6559\u6388\u3089\u306e\u7814\u7a76\u6210\u679c\u304c\u30aa\u30f3\u30e9\u30a4\u30f3\u30b8\u30e3\u30fc\u30ca\u30eb\u300eGenome Biology\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<p>\u533b\u5b66\u90e8\u533b\u5b66\u79d1\u57fa\u790e\u533b\u5b66\u7cfb\u306e\u5927\u585a\u6b63\u4eba\u51c6\u6559\u6388\u3068\u7c73\u56fd\u30cd\u30d6\u30e9\u30b9\u30ab\u5927\u5b66\u3001\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u9ad8\u52b9\u7387\u3067\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3002\uff15\u670817\u65e5\uff08\u30a4\u30ae\u30ea\u30b9\u6642\u9593\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u30b8\u30e3\u30fc\u30ca\u30eb\u300e<a title=\"Genome\" href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-017-1220-4\" target=\"_blank\" rel=\"noopener noreferrer\">Genome Biology<\/a>\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u907a\u4f1d\u5b50\u3092\u4eba\u70ba\u7684\u306b\u64cd\u4f5c\u3057\u3066\u4f5c\u88fd\u3055\u308c\u308b\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u306f\u3001\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u89e3\u6790\u5b9f\u9a13\u3084\u30d2\u30c8\u75be\u60a3\u306e\u30e2\u30c7\u30eb\u52d5\u7269\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u308b\u3001\u6975\u3081\u3066\u91cd\u8981\u306a\u30c4\u30fc\u30eb\u306e\u4e00\u3064\u3067\u3059\u3002\u305d\u306e\u4e2d\u3067\u3082\u7279\u306b\u4f7f\u7528\u983b\u5ea6\u304c\u9ad8\u3044\u306e\u304c\u3001\u30ec\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\u3084\u7d44\u63db\u3048\u9175\u7d20\u907a\u4f1d\u5b50\u306a\u3069\u3092\u633f\u5165\u3057\u305f\u30ce\u30c3\u30af\u30a4\u30f3\u30de\u30a6\u30b9\u3068\u3001\u7279\u5b9a\u306e\u6642\u671f\u304b\u3064\u7279\u5b9a\u306e\u7d44\u7e54\u3067\u7279\u7570\u7684\u306b\u907a\u4f1d\u5b50\u3092\u7834\u58ca\u3059\u308b\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\uff08loxP\u3068\u547c\u3070\u308c\u308bDNA\u914d\u5217\u304c\u633f\u5165\u3055\u308c\u3066\u3044\u308b\uff09\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u306e\u9700\u8981\u306e\u7d04\uff19\u5272\u3092\u3057\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u3092\u4f5c\u88fd\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u30b2\u30ce\u30e0\u4e2d\u306e\u6a19\u7684\u3068\u3059\u308b\u5834\u6240\u306b\u76ee\u7684\u306eDNA\u914d\u5217\u3092\u633f\u5165\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u8fd1\u5e74\u958b\u767a\u3055\u308c\u305f\u300cCRISPR\u30b2\u30ce\u30e0\u7de8\u96c6\u6cd5\u300d\u3092\u7528\u3044\u305f\u5834\u5408\u3001\u5358\u7d14\u306a\u907a\u4f1d\u5b50\u7834\u58ca\u306f\u7c21\u5358\u306b\u3067\u304d\u307e\u3059\u304c\u3001\u30b2\u30ce\u30e0\u306e\u72d9\u3063\u305f\u4f4d\u7f6e\u306b\u76ee\u7684\u306eDNA\u3092\u633f\u5165\u3059\u308b\u6280\u8853\u306b\u95a2\u3057\u3066\u306f\u3044\u307e\u3060\u306b\u52b9\u7387\u304c\u4f4e\u3044\u3068\u3044\u3063\u305f\u8ab2\u984c\u304c\u3042\u308a\u3001\u65b0\u305f\u306a\u907a\u4f1d\u5b50\u633f\u5165\u624b\u6cd5\u306e\u78ba\u7acb\u304c\u5f37\u304f\u671b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u306e\u307e\u307e\u306e\u300c\u4e8c\u672c\u9396DNA\u300d\u306b\u6bd4\u3079\u3066\u3001\u7247\u65b9\u306e\u307f\u306e\u300c\u4e00\u672c\u9396DNA\u300d\u3092\u7528\u3044\u305f\u5834\u5408\u306e\u907a\u4f1d\u5b50\u633f\u5165\u52b9\u7387\u304c\u9ad8\u3044\u3053\u3068\u306b\u7740\u76ee\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u300c\u9577\u9396\u4e00\u672c\u9396DNA\u300d\u306e\u5408\u6210\u6cd5\u3092\u78ba\u7acb\u3057\u3001\u300cCRISPR\u30b2\u30ce\u30e0\u7de8\u96c6\u6cd5\u300d\u3092\u7528\u3044\u3066\u9577\u3055400\u5869\u57fa\u7a0b\u5ea6\u306e\u914d\u5217\u306eDNA\u3092\u30b2\u30ce\u30e0\u306b\u633f\u5165\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3001\u3053\u306e\u6280\u8853\u3092\u7d041000\uff5e1500\u5869\u57fa\u306e\u633f\u5165\u306b\u767a\u5c55\u3055\u305b\u308b\u3068\u3068\u3082\u306b\u3001CRISPR\u30ea\u30dc\u6838\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u3068\u6bd4\u3079\u306610\u500d\u4ee5\u4e0a\u3082\u907a\u4f1d\u5b50\u633f\u5165\u52b9\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u30ce\u30c3\u30af\u30a4\u30f3\u30de\u30a6\u30b9\u4f5c\u88fd\u3084\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u4f5c\u88fd\u306b\u5fdc\u7528\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u65b9\u6cd5\u306f\u3001\u300c<em>Easi<\/em>-CRISPR \uff08Efficient additions with ssDNA inserts-CRISPR\uff09\u6cd5\u300d\u3068\u547d\u540d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u5927\u585a\u51c6\u6559\u6388\u306f\u3001\u300c\u672c\u5b66\u3068\u30cd\u30d6\u30e9\u30b9\u30ab\u5927\u5b66\u3001\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u306e\u3044\u305a\u308c\u306e\u7814\u7a76\u65bd\u8a2d\u3067\u3082\u7c21\u5358\u306b\u76ee\u7684\u306e\u30de\u30a6\u30b9\u304c\u4f5c\u88fd\u3067\u304d\u305f\u3053\u3068\u304b\u3089\u3001\u300e<em>Easi<\/em>-CRISPR\u6cd5\u300f\u306f\u975e\u5e38\u306b\u518d\u73fe\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u8ad6\u6587\u63b2\u8f09\u76f4\u5f8c\u304b\u3089\u3001\u300e<em>Easi<\/em>-CRISPR\u6cd5\u300f\u306e\u8a73\u7d30\u306b\u95a2\u3059\u308b\u8cea\u554f\u3084\u8b1b\u6f14\u306e\u4f9d\u983c\u306a\u3069\u3001\u56fd\u5185\u5916\u306e\u305f\u304f\u3055\u3093\u306e\u7814\u7a76\u8005\u304b\u3089\u306e\u30ea\u30af\u30a8\u30b9\u30c8\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u624b\u6cd5\u304c\u4e16\u754c\u4e2d\u3067\u4f7f\u7528\u3055\u308c\u308b\u3053\u3068\u3001\u307e\u305f\u3001\u30de\u30a6\u30b9\u4ee5\u5916\u306e\u751f\u7269\u7a2e\u3067\u306e\u907a\u4f1d\u5b50\u6539\u5909\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u3078\u306e\u5fdc\u7528\u306a\u3069\u306b\u3082\u751f\u304b\u3055\u308c\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3082\u3001\u4f4e\u30b3\u30b9\u30c8\u3001\u9ad8\u52b9\u7387\u3067\u7c21\u4fbf\u306b\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u3001\u533b\u5b66\u30fb\u751f\u7269\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3057\u305f\u3044\u300d\u3068\u8a71\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3010\u53c2\u8003\u6587\u732e\u3011<br \/>Quadros RM, Miura H, et al. Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biol. 2017 May 17;18(1):92. <br \/>doi:10.1186\/s13059-017-1220-4.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"682\" class=\"wp-image-1989\" title=\"\u5927\u585a\u5148\u751f_525.jpg\" src=\"https:\/\/www.u-tokai.ac.jp\/tachyon\/sites\/38\/2021\/05\/4b46cae2b5971ea13c78d70e4ada3e5f.jpg\" alt=\"\u5927\u585a\u5148\u751f_525.jpg\" srcset=\"https:\/\/www.u-tokai.ac.jp\/tachyon\/sites\/38\/2021\/05\/4b46cae2b5971ea13c78d70e4ada3e5f.jpg?resize=525%2C682&amp;zoom=1 525w, https:\/\/www.u-tokai.ac.jp\/tachyon\/sites\/38\/2021\/05\/4b46cae2b5971ea13c78d70e4ada3e5f.jpg?resize=525%2C682&amp;zoom=0.5 263w, https:\/\/www.u-tokai.ac.jp\/tachyon\/sites\/38\/2021\/05\/4b46cae2b5971ea13c78d70e4ada3e5f.jpg?resize=525%2C682&amp;zoom=0.25 131w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" data-recalc-dims=\"1\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u533b\u5b66\u90e8\u533b\u5b66\u79d1\u57fa\u790e\u533b\u5b66\u7cfb\u306e\u5927\u585a\u6b63\u4eba\u51c6\u6559\u6388\u3068\u7c73\u56fd\u30cd\u30d6\u30e9\u30b9\u30ab\u5927\u5b66\u3001\u6771\u4eac\u533b\u79d1\u6b6f\u79d1\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u9ad8\u52b9\u7387\u3067\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3002\uff15\u670817\u65e5\uff08\u30a4\u30ae\u30ea\u30b9\u6642\u9593\uff09\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u30b8\u30e3\u30fc\u30ca\u30eb\u300eGenome Biolog [&hellip;]<\/p>\n","protected":false},"author":41,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ep_exclude_from_search":false,"assignees":[],"_attachment_show_hide":false,"_tokai_univ_thumbnail":0,"_tokai_univ_thumbnail_url":"","_network_post_url":"","footnotes":"","tokai_univ_priority":0},"categories":[1],"tags":[],"class_list":["post-1249","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - 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