荒井 堅太

Arai Kenta

  • 講師
  • 学位:博士(理学)

基本情報

所属

  • Undergraduate School of Science / Department of Chemistry
  • Graduate School of Science / Course of Chemistry

ジャンル

  • Chemistry

研究と関連するSDGs

  • Responsible Consumption and Production

詳細情報

研究キーワード

  • Protein folding
  • Enzyme model
  • Neurodegenerative diseases
  • Peptide synthesis
  • Flow chemistry

研究分野

  • Life sciences Bioorganic chemistry

受賞

  • TU Science Award 2020
  • SeS redox & catalysis Bentham Current Green Chemistry Award for an excellent poster presentation

論文

S‐Denitrosylase‐like Activity of Cyclic Diselenides Conjugated with Xaa‐His Dipeptide: Role of Proline Spacer as a Key Activity Booster

Flexible Folding: Disulfide-Containing Peptides and Proteins Choose the Pathway Depending on the Environments

Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates

Relaxin-2 May Suppress Endometriosis by Reducing Fibrosis, Scar Formation, and Inflammation

Basic Amino Acid Conjugates of 1,2-Diselenan-4-amine with Protein Disulfide Isomerase-like Functions as a Manipulator of Protein Quality Control

Modeling Thioredoxin Reductase-Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH...Se Hydrogen Bond through Stabilization of the Mixed Se-S Intermediate

Cyclic telluride reagents with remarkable glutathione peroxidase-like activity for purification-free synthesis of highly pure organodisulfides

Coupling effects of thiol and urea-type groups for promotion of oxidative protein folding

Oxidative Protein Folding Using trans-3,4-Dihydroxyselenolane Oxide.

Characterization and optimization of two-chain folding pathways of insulin via native chain assembly

Protein Folding in the Presence of Water-Soluble Cyclic Diselenides with Novel Oxidoreductase and Isomerase Activities

Mechanism of radioprotection by dihydroxy-1-selenolane (DHS): Effect of fatty acid conjugation and role of glutathione peroxidase (GPx)

Organoselenium compounds: A new class of oxidative folding reagent

Selenoglutathione Diselenide: Unique Redox Reactions in the GPx-Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein

Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue

Glutathione Peroxidase-Like Activity of Amino-Substituted Water-Soluble Cyclic Selenides: A Shift of the Major Catalytic Cycle in Methanol

Rapid Electrochemical Conversion of Thiol and Disulfide into Difluoro- and Trifluoromethyl Thioethers in a Microfluidic Reactor

Tetrahydroselenophene. A Unique Structural Motif for Biochemical Applications

Alkyl chain modulated cytotoxicity and antioxidant activity of bioinspired amphiphilic selenolanes

Effects of Ring Size and Polar Functional Groups on the Glutathione Peroxidase-Like Antioxidant Activity of Water-Soluble Cyclic Selenides

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