Iejima Daisuke

論文

Clinical features and molecular mechanisms of RP1L1 variants causing occult macular dystrophy.

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.

The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis.

Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques

Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro.

Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association

Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency

Novel biallelic loss-of-function KCNV2 variants in cone dystrophy with supernormal rod responses.

Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis.

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma.

Significance of optineurin mutations in glaucoma and other diseases.

CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.

HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/deletion nucleotides located at the 3' end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration.

HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration.

Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice.

Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.

A compact, automated cell culture system for clinical scale cell expansion from primary tissues.

FRS2β, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding

Odontoblast marker gene expression is enhanced by a CC-chemokine family protein MIP-3α in human mesenchymal stem cells

Differential inducibility of human and porcine dental pulp-derived cells into odontoblasts.

共同研究・競争的資金等の研究課題

Function analysis for HTRA1 in AMD neovascularization.

Characterization of HtrA1 Promoter in Patients with Exudative Age-Related Macular Degeneration.