一村 義信

論文

Development of p62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development

Activation of p62/SQSTM1-Keap1-Nuclear Factor erythroid 2-Related Factor 2 Pathway in Cancer

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

P62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

共同研究・競争的資金等の研究課題

リン酸化によるp62の動態調節機構とその生理機能の解明

選択的オートファジーレセプターp62のリン酸化制御機構とその生理的意義の解明

新規ストレス応答機構p62-Keap1-Nrf2システムの制御メカニズムの解明

リン酸化p62とオートファジーが関与するシグナル伝達機構の解明

選択的オートファジーによる細胞内クリアランスの制御

放射線の変異誘導を抑制するヒトの生理機構におけるシャペロンとオートファジーの役割

損傷DNA修復に関わる小胞体分子シャペロンGRP78の作用機構