石井 恭正

Ishii Takamasa

  • 准教授
  • 学位:博士(医学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

ジャンル

  • Fishing
  • Marine Products
  • Regional Revitalization
  • Community Relations

研究と関連するSDGs

  • Gender Equality
  • Sustainable Cities and Communities
  • Life Below Water

詳細情報

研究キーワード

  • Mitochondria
  • Replication stress
  • Energy metabolism
  • Redox regulation
  • Oxidative stress
  • Aging

研究分野

  • Life sciences Physiology
  • Life sciences Experimental pathology
  • Life sciences Functional biochemistry
  • Life sciences Nutrition and health science
  • Life sciences Medical biochemistry

受賞

  • Tokai University Young Investigator Award
  • Society for Free Radical Research JAPAN Young Investigator Award
  • The Japanese Radiation Research Society Young Investigator Award
  • Society for Free Radical Research-Asia, and Japanese Society of Mitochondrial Research and Medicine The 5th Biennial Meeting, and 11th Conference, Young Investigator Award
  • Cytoprotection研究会 Young Investigator Award
  • Asian Society for Mitochondrial Research and Medicine, and Japanese Society for Mitochondrial Research and Medicine International Conference on Mitochondria and Life 2005, Young Investigator Award
  • International Association of Gerontology & Geriatrics (IAGG) The 7th Asia/Oceania Regional Congress of Gerontology, Poster Award
  • Japan Society for Biomedical Gerontology Young Investigator Award

論文

Metabolic Biomarkers in Nematode C. elegans During Aging.

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain

Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models

A Combination of Mitochondrial Oxidative Stress and Excess Fat/Calorie Intake Accelerates Steatohepatitis by Enhancing Hepatic CC Chemokine Production in Mice

Oxidative stress tolerance of early stage diabetic endothelial progenitor cell

Correction: Oxidative stress induced inflammation initiates functional decline of tear production.

Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion

Predicting longevity in C-elegans: Fertility, mobility and gene expression

Model animals for the study of oxidative stress from complex II

Model animals for the study of oxidative stress from complex II.

A new mouse model of dry eye disease: Oxidative stress affects functional decline in the Lacrimal Gland

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

Mitochondrial Superoxide Anion Overproduction in Tet-mev-1 Transgenic Mice Accelerates Age-Dependent Corneal Cell Dysfunctions

Mitochondrial superoxide anion (O-2(center dot-)) inducible "mev-1" animal models for aging research

Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation

Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans

Genetic and Maternal Effects on Valproic Acid Teratogenesis in C57BL/6J and DBA/2J Mice

Post-dauer Life Span of Caenorhabditis Elegans Dauer Larvae Can be Modified by X-irradiation

The Role of Mitochondrial Superoxide Anion(O-2(-)) on Physiological Aging in C57BL/6J Mice

講演・口頭発表等

  • 電子伝達系障害酸化ストレスに対する適応応答の加齢変化
  • レドックスとエネルギー代謝の時空間的制御機構解明から見える新たな疾病制御戦略 ミトコンドリアレドックス制御の加齢変化
  • 電子伝達系異常酸化ストレスによる自然免疫応答と大細胞肺がん
  • 4-HNEを標的とした自然免疫応答を伴う大細胞肺がんの発癌機序
  • 酸化ストレス依存的な自然免疫応答の慢性化を伴う非小細胞肺がんの発癌機序
  • モデル生物「線虫」を用いたストレス応答研究の展開 線虫C.elegansのMXL-3転写因子の酸化ストレス応答
  • SDHC変異傍神経節腫モデルマウスでの過酸化脂質による自然免疫の惹起と炎症の慢性化
  • 酸化ストレス下における転写因子MXL‐3の機能
  • 線虫C.elegansのMXL‐3転写因子の酸化ストレス応答
  • ミトコンドリア電子伝達系傷害に伴う慢性的酸化ストレス負荷による脳内グリア環境の加齢変化
  • Type‐1 Fiber萎縮に関わる血流と遺伝子発現動態の解析と特徴
  • ミトコンドリア複合体II電子伝達異常に伴う組織間質への加齢依存的リンパ球浸潤の亢進
  • SDHC変異傍神経節腫モデルマウスでの加齢依存的炎症反応の惹起と慢性化機序
  • 酸化ストレスと老化のモデル研究
  • 基礎老化研究 酸化ストレスと老化のモデル研究
  • 造腫瘍性SDHC変異モデルマウスでの加齢依存的炎症応答の解析
  • 線虫C.elegansのMXL‐3転写因子の酸化ストレス応答
  • ミトコンドリア由来酸化ストレスによる脂肪性肝炎の線維化促進機序の解明
  • 線虫C.elegansのMXL-3転写因子の酸化ストレス応答
  • ミトコンドリア複合体II電子伝達異常に起因する酸化ストレスと生体の加齢変容

所属学会

  • THE JAPANESE CANCER ASSOCIATION
  • THE JAPANESE BIOCHEMICAL SOCIETY
  • THE JAPANESE RADIATION RESEARCH SOCIETY
  • THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE
  • SOCIETY FOR FREE RADICAL RESEARCH JAPAN
  • JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY

産業財産権

  • A Transgenic Cell And Gene Recombinant Animal Having A mutant SDHC Gene Derived From Mammals
  • Expression vector capable of regulating the induction of foreign gene expression

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