三橋 弘明

Mitsuhashi Hiroaki

  • 准教授
  • 学位:博士(学術)

基本情報

所属

  • Undergraduate School of Engineering / Department of Applied Biochemistry
  • Graduate School of Science and Technology / Course of Science and Technology
  • Graduate School of Engineering / Course of Applied Science
  • Micro/Nano Technology Center

ジャンル

  • Biotechnology

研究と関連するSDGs

  • Good Health and Well-Being

詳細情報

研究キーワード

  • nuclear envelopathy
  • lamin A
  • DUX4
  • genome editing
  • zebrafish
  • FSHD
  • muscular dystrophy
  • hereditary disorders

研究分野

  • Life sciences Laboratory animal science zebrafish
  • Life sciences Pathobiochemistry muscular dystrophy
  • Life sciences Genomics
  • Life sciences Molecular biology
  • Life sciences Neurology neuromuscular disorders

論文

Nanopore direct RNA sequencing detects DUX4-activated repeats and isoforms in human muscle cells.

Comprehensive genomic analysis reveals dynamic evolution of endogenous retroviruses that code for retroviral-like protein domains.

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.

Comprehensive genomic analysis reveals dynamic evolution of mammalian transposable elements that code for viral-like protein domains

Structural instability of lamin A tail domain modulates its assembly and higher order function in Emery-Dreifuss muscular dystrophy.

Tandem-genotypes: robust detection of tandem repeat expansions from long DNA reads.

Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers.

Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis.

Functional domains of the FSHD-associated DUX4 protein.

Nanopore-based single molecule sequencing of the D4Z4 array responsible for facioscapulohumeral muscular dystrophy

Data describing the effect of DRD4 promoter polymorphisms on promoter activity.

Splicing of human chloride channel 1.

Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.

Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.

A beta induces oxidative stress in senescence-accelerated (SAMP8) mice

Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes

ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1

Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy

Expression of DUX4 in zebrafish development recapitulates facioscapulohumeral muscular dystrophy

A high-salinity solution with calcium chloride enables RNase-free, easy plasmid isolation within 55 minutes

書籍等出版物

  • Zebrafish, Medaka, and other small fishes : new model animals in biology, medicine, and beyond

講演・口頭発表等

  • The role of estrogen regulation in FSHD-1
  • Expression of human DUX4 in zebrafish development
  • Filamin C is required for the maintenance of sarcomere structure in medaka

担当経験のある科目

  • Biochemistry 1
  • Fundamental science and engineering 1, 2

共同研究・競争的資金等の研究課題

Functional analysis of DUX4 and its effect on development.

Expression of Human DUX4 in Zebrafish Development

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Inquiries about coverage

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