Hosokawa Hiroyuki

論文

Targeting Notch Signaling to Restore Neural Development and Behavior in Autism

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1

Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells

GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma

Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells

Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells

Transcription factors regulate early T cell development via redeployment of other factors

How transcription factors drive choice of the T cell fate

Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching

Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development

AMBRA1 controls antigen-driven activation and proliferation of naïve T cells.

Cell type–specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells

Mechanisms of action of hematopoietic transcription factor PU.1 in initiation of T-cell development

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

共同研究・競争的資金等の研究課題

Notch-dependent functional conversion of RUNX transcription factors regulates the initiation of T-lineage program

Are the cell-type specific actions of master transcription factors controlled by the organization of functional protein complexes?

Stage-specific roles of Notch signaling on induction of T cell development from hematopoietic progenitor cells

Elucidation of pathogenic immune memory formation and maintenance

Functions of posttranscriptional regulation of GATA3 in Th2 cells

Identification of the functional molecular complexes of GATA3 in Th2 cells.

Regulation of chromatin remodeling in differentiation and maintenance of Th1/Th2 cells