Miura Hiromi

論文

Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT

Delivering mRNAs to mouse tissues using the SEND system.

Improved Genome Editing via Oviductal Nucleic Acids Delivery (i-GONAD): Protocol Steps and Additional Notes.

CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice.

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway.

Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools.

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

Thy1 promoter activity in the Rosa26 locus in mice: lessons from Dre-rox conditional expression system.

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.

Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma.

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Creation of CRISPR-based germline-genome-engineered mice without ex vivo handling of zygotes by i-GONAD.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Rescue of Coat Color Phenotypes in Mutant Mice Using the Gonad Method

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice.

i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases.

Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors.

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

Three-dimensional X-ray visualization of axonal tracts in mouse brain hemisphere.

Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery.

共同研究・競争的資金等の研究課題

Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

Establishment of gene expression system by intron modification and its application for the functional analysis of diabetes-related genes

Easi-CRISPR for creating genetically modified mice using long ssDNA.

Development of novel method for generation of genome editing mice without ex vivo handling of embryos

Developmentandapplicationofmouseandcellmodelsforanalyses of HLA-dependent adverse drug reactions