Hadano Shinji

論文

Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing.

Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.

Genetic and clinical characteristics of ALS patients with NEK1 gene variants.

Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.

SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron.

Impact of COVID-19 infection on clinical care: Insights from interviews with multidisciplinary healthcare professionals involved in amyotrophic lateral sclerosis patients.

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells.

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.

Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures.

ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.

Monitoring the autophagy-endolysosomal system using monomeric Keima-fused MAP1LC3B.

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons

Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function.

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model.

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice.

共同研究・競争的資金等の研究課題

A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomes

Elucidation of microRNAs causing immune cell dysfunction by next generation sequencer in patients with lung cancer

Molecular mechanism for the maintenance of proteostasis in motor neurons

Toward a development of the novel drug-screening system based on monitoring autophagy dynamics

Towards a comprehensive understanding of molecular pathogenesis for amyotrophic lateral sclerosis

Elucidation of the physiological function of ALS2 and mechanism for motor neuron degeneration through the identification of ALS2 activators