小島 直也

Kojima Naoya

  • 教授
  • 学位:理学博士

基本情報

所属

  • Undergraduate School of Engineering / Department of Applied Biochemistry
  • Graduate School of Engineering / Course of Applied Science

詳細情報

研究キーワード

  • Glycoconjugates
  • Carbohydrates

研究分野

  • Life sciences Immunology
  • Nanotechnology/Materials Nanobioscience
  • Life sciences Cell biology
  • Life sciences Functional biochemistry
  • Life sciences Structural biochemistry

論文

Importance of particle size of oligomannose-coated liposomes for induction of Th1 immunity.

In vitro activation and maturation of human mononuclear phagocytes by stimulation with liposomes coated with a neoglycolipid containing α1-3, α1-6-mannotriose.

In vitro uptake of oligomannose-coated liposomes leads to differentiation of inflammatory monocytes into mature antigen-presenting cells that can activate T cells

Requirement of TLR4 signaling for the induction of a Th1 immune response elicited by oligomannose-coated liposomes

Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

SIGNR1-mediated phagocytosis, but not SIGNR1-mediated endocytosis or cell adhesion, suppresses LPS-induced secretion of IL-6 from murine macrophages

Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice

Vaccination with profilin encapsulated in oligomannose-coated liposomes induces significant protective immunity against Toxoplasma gondii

Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule

C-type lectin receptor SIGNR1 expressed on peritoneal phagocytic cells with an immature dendritic cell-like phenotype is involved in uptake of oligomannose-coated liposomes and subsequent cell maturation

Oligomannose-coated liposome-entrapped dense granule protein 7 induces protective immune response to Neospora caninum in cattle

Effective stimulation of invariant natural killer T cells by oligomannose-coated liposomes

Oligomannose-Coated Liposome as a Novel Adjuvant for the Induction of Cellular Immune Responses to Control Disease Status

Genetic diversity of Theileria orientalis in tick vectors detected in Hokkaido and Okinawa, Japan

Preferences for uptake of carbohydrate-coated liposomes by C-type lectin receptors as antigen-uptake receptors

Development of Novel Carbohydrate-Coated Liposome-Based Vaccines

Targeting with oligomannose-coated liposomes promotes maturation and splenic trafficking of dendritic cells in the peritoneal cavity

Development of peritoneal macrophage along a dendritic cell lineage in response to uptake of oligomannose-coated liposomes

Anti-allergic potential of oligomannose-coated liposome-entrapped Cry j 1 as immunotherapy for Japanese cedar pollinosis in mice

SIGNR1 ligation on murine peritoneal macrophages induces IL-12 production through NF kappa B activation

書籍等出版物

  • Chapter 46, ST8Sia II (STX)

所属学会

  • THE JAPANESE CANCER ASSOCIATION
  • THE JAPANESE SOCIETY FOR IMMUNOLOGY
  • Japanese Society of Carobohydrate
  • Japanese Society of Biochemistry

共同研究・競争的資金等の研究課題

Analysis of target molecules and their effective carbohydrates for Helicobacter pyrori

Molecular mechanism of Guillain-Barre syndrome after Campylobacter jejuni enteritis : approach from bacterial analysis

Analysis of receptor carbohydrates for Helicobacter pylori from human fluds

Analysis of two types of sialytransferases involved in polysialic acid synthesis

Molecular analysis of neural differentiation induced by glycosyltransferase

Induction of differentiation of neural cells by remodeling of ganglioside synthesis and expression

Study on carbohydrate Structure and Functions.

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