椎名 隆

Shiina Takashi

  • 教授
  • 学位:博士(畜産学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

研究と関連するSDGs

  • Good Health and Well-Being

詳細情報

研究キーワード

  • Major Histocompatibility Complex; MHC

研究分野

  • Life sciences Molecular biology
  • Life sciences Laboratory animal science
  • Life sciences Genetics

論文

Genetic Links between Reproductive Traits and Amino Acid Pairwise Distances of Swine Leukocyte Antigen Alleles among Mating Partners in Microminipigs

Liposome-encapsulated progesterone efficiently suppresses B-lineage cell proliferation

Pathologic Features of Anti-Ku Myositis.

Coccomyxa subellipsoidea KJ Components Enhance the Expression of Metallothioneins and Th17 Cytokines during Human T Cell Activation

Regulatory SVA retrotransposons and classical HLA genotyped-transcripts associated with Parkinson’s disease

Characterization of the polymorphisms of dog MHC genes and intra- and interbreed DLA haplotype diversity

MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques

MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques.

Pre-existing cross-reactive neutralizing activity against SARS-CoV-2 and seasonal coronaviruses prior to the COVID-19 pandemic (2014-2019) with limited immunity against recent emerging SARS-CoV-2 variants, Vietnam

Association Between HLA Alleles and Autoantibodies in Dermatomyositis Defined by Sarcoplasmic Expression of Myxovirus Resistance Protein A.

Idiotope-Driven T-Cell/B-Cell Collaboration-Based T-Cell Epitope Prediction Using B-Cell Receptor Repertoire Sequences in Infectious Diseases.

Large-Scale Polymorphism Analysis of Dog Leukocyte Antigen Class I and Class II Genes (DLA-88, DLA-12/88L and DLA-DRB1) and Comparison of the Haplotype Diversity between Breeds in Japan.

Nucleotide alterations in the HLA-C class I gene can cause aberrant splicing and marked changes in RNA levels in a polymorphic context-dependent manner.

Construction of the systemic anticancer immune environment in tumour-bearing humanized mouse by using liposome-encapsulated anti-programmed death ligand 1 antibody-conjugated progesterone.

Association of immune-mediated necrotizing myopathy (IMNM) with HLA polymorphisms.

Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes.

Competency of iPSC-derived retinas in MHC-mismatched transplantation in non-human primates.

Vitamin C Maintenance against Cell Growth Arrest and Reactive Oxygen Species Accumulation in the Presence of Redox Molecular Chaperone hslO Gene.

Immunodeficiency in patients with thymoma-associated myasthenia gravis.

Genetic Association between Farrowing Rates and Swine Leukocyte Antigen Alleles or Haplotypes in Microminipigs.

書籍等出版物

  • Nucleotide sequence determination of the 1.8Mb segment in the HLA class (]G0001[) region

講演・口頭発表等

  • NGSによるHLA DNAタイピング法の特徴と臨床応用
  • 海外から輸送したカニクイザル凍結精子による産子獲得
  • ネコMHCクラスII遺伝子のRNA発現解析およびハプロタイプ推定
  • 封入体筋炎とHLA-DRB1多型との関連解析
  • 大腸菌のhslO遺伝子はRecA非依存性染色体維持および遺伝子水平移動に関与する。
  • 犬のがんペプチドワクチン療法のための各種DLA‐88型拘束性TRP‐2ペプチドの同定
  • 免疫介在性壊死性ミオパチー(IMNM)とHLA-DRB1多型との関連解析
  • NGS-SBT法に関するワークショップ
  • 免疫介在性壊死性ミオパチー(IMNM)とHLA-DRB1多型との関連解析

Works(作品等)

Comparative genome sequence analysis of MHC region

共同研究・競争的資金等の研究課題

Search for genes involved in the mechanism of immune-mediated necrotizing myopathy

Study on molecular mechanism of collagen-induced arthritis in cynomolgus monkeys

Genetic analysis of neo-self

An analysis of HLA-LOH in relapsed tumor by using NGS after allogeneic stem cell transplantation

Search for host factors in severe influenza virus infection using a nonhuman primate model

Development of cultured skin which has tolerance in ischemia.

Developing the Universal iPS cell lines using genetic engineering system

High-throughput sequencing method of the KIR haplotype for clinical applications

Elucidation of comprehensive MHC information in common marmoset for biomedical studies

Analysis of genetic diversity of the extended MHC region of Japanese quail

Integrated redearch for HLA disease and evolution

HLA genome diversity analyses by resequencing

Basic improvement for Microminipigs: Preparation of MHC fixed pigs and analyses of the cellular immunological features

Exome sequencing of drug-metabolizing enzyme and transporter (DMET) genes and immune related genes in cynomolgus macaque.

Establishment of a macaque cancer model using cancer cells derived from MHC homozygous macaque iPS cells

Exome sequencing for disease gene discovery in rheumatoid arthritis

Establishment of a network of model-monkey supply forhuman medical researches

ResearchMapへ移動します

Contact Us

Inquiries about coverage

Public Affairs Division Public Affairs and Communications Department

Tel. 0463-63-4670(direct dialing)