Kimura Hiroshi

論文

An Open-Access Dialysis Membrane-Integrated Microfluidic Device for Generating Drug Exposure Profiles Through Molecular-Weight-Dependent Transport

Material-dependent oxygen transport governs ischemia-reperfusion injury and drug response in a kidney microphysiological system

The intrinsic impact of mechanical stress on the maintenance of oocyte dormancy

Metabolism-dependent drug response assessment using a liver-cancer microphysiological system on the kinetic-pump integrated microfluidic plate (KIM-Plate)

An oxygen-permeable, stirrer-pump-integrated liver–heart microphysiological system enables time-resolved analysis in PK–PD relationships of metabolism-dependent cardiotoxicity

Double-Layered Microphysiological System Made of Polyethylene Terephthalate with Trans-Epithelial Electrical Resistance Measurement Function for Uniform Detection Sensitivity

The Fluidic Shear Stress Loading Method Enables Mechanobiological Stimulation in an On-Chip Pump-Integrated Microphysiological System

Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device

An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling

A Dialysis Membrane-Integrated Microfluidic Device for Controlled Drug Retention and Nutrient Supply

A Microfluidic Device Integrating a Glucose Sensor and Calibration Function for Cell-Based Assays

Evaluation of Perfusion Cell Culture Conditions in a Double-Layered Microphysiological System Using AI-Assisted Morphological Analysis

Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-

Development of the membrane ceiling method for in vitro spermatogenesis

Functional Evaluation of Commercially Available Human Renal Proximal Tubular Epithelial Cells

Discrete element method-based simulation system for predicting natural stone evacuation pathways in patients with urolithiasis

Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut

Thin microporous polydimethylsiloxane membrane prepared by phase separation and its applications for cell culture

Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis

Microphysiological systems for realizing microenvironment that mimics human physiology—functional material and its standardization applied to microfluidics

共同研究・競争的資金等の研究課題

Development of gut microphysiological system through functional element reconstruction approach

Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems

Cell-cycle property and regulation in mouse sperm stem cells

Novel tubular homeostatic mechanism mediated by primary cilia

A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier

A hydrogen isotope separation method based on the Ludwig-Soret effect

Imaging device development for hyperpolarization response analysis forming neural activity rhythm

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Ensuring integrity of gametogenesis

Establishment of in vitro spermatogenesis with high integrity

An integrated body-on-a-chip mimicking physiological parameters