木村 啓志

Kimura Hiroshi

  • 准教授
  • 学位:博士(工学)

基本情報

所属

  • Undergraduate School of Engineering / Department of Mechanical Engineering
  • Graduate School of Science and Technology / Course of Science and Technology
  • Graduate School of Engineering / Course of Mechanical Engineering
  • Micro/Nano Technology Center

ジャンル

  • Biotechnology

研究と関連するSDGs

  • Good Health and Well-Being
  • Responsible Consumption and Production

詳細情報

研究キーワード

  • MicroTAS
  • Microphysiological System
  • BIo MEMS
  • Microfluidic device
  • Bioengineering

研究分野

  • Nanotechnology/Materials Nano/micro-systems

論文

A novel method for successful induction of interdigitating process formation in conditionally immortalized podocytes from mice, rats, and humans

A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system.

Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control.

Diversity in self-organized forms and migration modes in isolated epithelial cells

C. elegans episodic swimming is driven by multifractal kinetics.

A Microfluidic Probe Integrated Device for Spatiotemporal 3D Chemical Stimulation in Cells.

A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies

Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress.

Visualization and isolation of zone-specific murine hepatocytes that maintain distinct cytochrome P450 oxidase expression in primary culture.

Heterogeneous Solvent Dielectric Relaxation in Polymer Solutions of Water and Alcohols

OP50, a bacterial strain conventionally used as food for laboratory maintenance of C. elegans, is a biofilm formation defective mutant.

In vitro spermatogenesis in two‐dimensionally spread mouse testis tissues

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons

Elucidation of isoflurane action mechanism on surgical diabetes using microfluidic device

Comprehensive analysis of chromatin signature and transcriptome uncovers functional lncRNAs expressed in nephron progenitor cells

Neonatal testis growth recreated in vitro by two-dimensional organ spreading

Quantitative analysis of sensitivity to a Wnt3a gradient in determination of the pole-to-pole axis of mitotic cells by using a microfluidic device.

講演・口頭発表等

  • Elucidation of isoflurane action mechanism on surgical diabetes using microfluidic device
  • 3Dプリンタで製作したマイクロ流体デバイスを用いる生体機能チップのモジュール化
  • マイクロ流体デバイス内への設置を目的とした血中循環腫瘍細胞用薄膜pH電極の高機能化
  • 生分解性ディスクの創製と高せん断応力下における血栓部位への接着挙動
  • グルコースセンサ集積型マイクロ流体デバイスを用いた細胞動態オンライン計測
  • マイクロ流体デバイスを用いたIn Vitro精巣組織培養法の改良
  • シリコン樹脂カバーを併用した精巣組織培養法による精子形成効率の向上
  • 肺がん検出用アセトン測定センサの開発
  • 老化メカニズム解明に向けた線虫動態定量化のためのマイクロ流体デバイスの構築
  • 細胞培養環境の恒常性維持に向けた透析膜集積型デバイスの開発
  • マイクロ流体デバイス技術を基盤とするOrgan/Body‐on‐chips
  • 眼病予防を指向したルテイン内包高分子超薄膜の調製と機能評価
  • マイクロ流体デバイス内血中循環腫瘍細胞用薄膜pH電極の高機能化
  • Development of multi-organs-on-a-chip mimicking physiological parameters: Evaluation of the function using prodrug CPT-11
  • 肝小葉のZonationに着目した肝臓構築のための基盤整備
  • Flow simulation around a kidney stone by using immersed boundary method
  • Evaluation of cell response to spatiotemporal chemical stimulation using a microfluidic probe integrated device
  • Patterning of gel substrate for cell culture using ink jet technology

所属学会

  • THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS
  • THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN
  • THE SOCIETY FOR CHEMISTRY AND MICRO-NANO SYSTEMS
  • THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

共同研究・競争的資金等の研究課題

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Ensuring integrity of gametogenesis

Establishment of in vitro spermatogenesis with high integrity

An integrated body-on-a-chip mimicking physiological parameters

In vitro system maintaining efficient spermatogenesis for a long duration

Development of an On-chip Simulator of Hepatic Lobule

Development of in vitro embryo culture system based-on microfluidics for artificial reproductive technology

Ischemic stroke therapy using quality and quantity-controlled culture system enriched in endothelial progenitor cells

Behavioral analyses of genes and cells in early mammalian development

An on-chip hepatic metabolism model for pharmacokinetic studies

Integrated "Body on a Chip" system for cell-based assay

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