木村 啓志

Kimura Hiroshi

  • 教授
  • 学位:博士(工学)

基本情報

所属

  • Undergraduate School of Engineering / Department of Bioengineering
  • Graduate School of Science and Technology / Course of Science and Technology
  • Graduate School of Engineering / Course of Mechanical Engineering
  • Micro/Nano Technology Center

ジャンル

  • Biotechnology

研究と関連するSDGs

  • Good Health and Well-Being
  • Responsible Consumption and Production

詳細情報

研究キーワード

  • Microphysiological System (MPS)
  • Bioengineering
  • Microfluidic device
  • MicroTAS
  • BIo MEMS

研究分野

  • Nanotechnology/Materials Nano/micro-systems

論文

In vitro spermatogenesis in isolated seminiferous tubules of immature mice

Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates

Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure controlled mechanical filtrating stress on a glomerulus-on-a-chip

Insulin signaling shapes fractal scaling of C. elegans behavior

Glomerulus-on-a-Chip: Current Insights and Future Potential Towards Recapitulating Selectively Permeable Filtration Systems

In vitro enzymatic electrochemical monitoring of glucose metabolism and production in rat primary hepatocytes on highly O2 permeable plates.

A novel method for successful induction of interdigitating process formation in conditionally immortalized podocytes from mice, rats, and humans

A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system.

Rat in vitro spermatogenesis promoted by chemical supplementations and oxygen-tension control.

Diversity in self-organized forms and migration modes in isolated epithelial cells

C. elegans episodic swimming is driven by multifractal kinetics.

A Microfluidic Probe Integrated Device for Spatiotemporal 3D Chemical Stimulation in Cells.

A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies

Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress.

Visualization and isolation of zone-specific murine hepatocytes that maintain distinct cytochrome P450 oxidase expression in primary culture.

Heterogeneous Solvent Dielectric Relaxation in Polymer Solutions of Water and Alcohols

Measurement and modelling of tensile moduli of polymer blend thin films with phase separated structures

OP50, a bacterial strain conventionally used as food for laboratory maintenance of C. elegans, is a biofilm formation defective mutant.

講演・口頭発表等

  • Michrophysiological System (MPS) Based on Microfluidic Technology for Safety
  • Status of the Japanese MPS project supported by AMED
  • Importance of Oxygen Supply in Engineering Physiological Tissues Both in Static Microplates and Perfused Microphysiogical Systems
  • Organs-On-A-Chip Systems with High Operability and Pumping Capability for Practical use in Drug Discovery
  • In vitro seminiferous tubule imaging method for high-magnification observation using an inverted microscope
  • Microphysiological System (MPS) Platforms with High Operability for Commercialization.

所属学会

  • THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS
  • THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN
  • THE SOCIETY FOR CHEMISTRY AND MICRO-NANO SYSTEMS
  • THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

共同研究・競争的資金等の研究課題

Novel tubular homeostatic mechanism mediated by primary cilia

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Ensuring integrity of gametogenesis

Establishment of in vitro spermatogenesis with high integrity

An integrated body-on-a-chip mimicking physiological parameters

In vitro system maintaining efficient spermatogenesis for a long duration

Development of an On-chip Simulator of Hepatic Lobule

Development of in vitro embryo culture system based-on microfluidics for artificial reproductive technology

Ischemic stroke therapy using quality and quantity-controlled culture system enriched in endothelial progenitor cells

Behavioral analyses of genes and cells in early mammalian development

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