Kimura Hiroshi

論文

Development of the membrane ceiling method for in vitro spermatogenesis

Discrete element method-based simulation system for predicting natural stone evacuation pathways in patients with urolithiasis

Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut

Advancements in Microphysiological Systems: Exploring Organoids and Organ-on-a-Chip Technologies in Drug Development -Focus on Pharmacokinetics Related Organs-

Thin microporous polydimethylsiloxane membrane prepared by phase separation and its applications for cell culture

Self-organization of spermatogenic wave coordinates sustained sperm production in the mouse testis

Microphysiological systems for realizing microenvironment that mimics human physiology—functional material and its standardization applied to microfluidics

Fabrication of microfluidic pH sensing chip based on sputtered Sb2O3/Sb thin film working electrode and AgIO3/Ag thin film reference electrode for detection of A549 cells

Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism

Standalone cell culture microfluidic device-based microphysiological system for automated cell observation and application in nephrotoxicity tests

Direct electron transfer kinetics of histamine dehydrogenase at air plasma-treated graphite nanofibers

Culture-space control is effective in promoting haploid cell formation and spermiogenesis in vitro in neonatal mice

Generation of rat offspring using spermatids produced through in vitro spermatogenesis

In vitro spermatogenesis in isolated seminiferous tubules of immature mice

Improvements in <i>in vitro</i> spermatogenesis: oxygen concentration, antioxidants, tissue-form design, and space control

Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates

Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure-controlled mechanical filtration stress on a glomerulus-on-a-chip

Insulin signaling shapes fractal scaling of C. elegans behavior

Glomerulus-on-a-Chip: Current Insights and Future Potential Towards Recapitulating Selectively Permeable Filtration Systems

In vitro enzymatic electrochemical monitoring of glucose metabolism and production in rat primary hepatocytes on highly O2 permeable plates.

共同研究・競争的資金等の研究課題

Development of gut microphysiological system through functional element reconstruction approach

Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems

Cell-cycle property and regulation in mouse sperm stem cells

Novel tubular homeostatic mechanism mediated by primary cilia

A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier

A hydrogen isotope separation method based on the Ludwig-Soret effect

Imaging device development for hyperpolarization response analysis forming neural activity rhythm

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Ensuring integrity of gametogenesis

Establishment of in vitro spermatogenesis with high integrity

An integrated body-on-a-chip mimicking physiological parameters