Hitoshi Tsugawa

論文

Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.

Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Development of a serological assay to simultaneously identify Helicobacter suis and Helicobacter pylori infection

THE MOLECULAR REASON WHY THE GUT COMMENSAL PATHOBIONT KLEBSIELLA PNEUMONIAE DISRUPTS THE EPITHELIAL BARRIER AND TRANSLOCATES TO THE LIVER

IDENTIFICATION OF NON-HELICOBACTER BACTERIA ESSENTIAL IN GASTRIC CARCINOGENESIS IN H. PYLORI-INFECTED STOMACH

Role of gastric non-Helicobacter commensal bacteria in the development of CD44v9-positive cancer stem cells

Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1

SHORT CHAIN FATTY ACIDS (SCFAS) DERIVED FROM GASTRIC NON-HELICOBACTER COMMENSAL BACTERIA COULD IMPART STEM-CELL PROPERTIES TO CD44V9-POSITIVE CELLS

Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.

Precision Medicine Approaches to Prevent Gastric Cancer

Neutrophil-activating protein polymorphism of Helicobacter pylori determines the host risk of dyspepsia.

Cancer stem-cell marker CD44v9-positive cells arise from Helicobacter pylori-infected CAPZA1-overexpressing cells.

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression.

Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

H. pylori infection enhanced cell invasion and proliferation via CagA accumulation in CD44v9-expressing cancer stem-like cells

Cystathionine beta-synthase and PGRMC1 as CO sensors

共同研究・競争的資金等の研究課題

Molecular mechanisms of the reason that gastric cancer patients are selected from H. pylori-infected patients

Development of a two-step molecular targeted therapy to eliminate gastric cancer stem cells and progenitor cells

Role of gastric microbiota on the development of gastric cacner stem-cells in H. pylori-infected gastric mucosa

Molecular characterization of H. pylori-infected cells associated with the development of gastric cancer

Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies

Exploitation of pathogenic gastrointestinal bacteria specific molecular tageting therapy

Host cell characteristics involved in gastric carcinogenesis by H. pylori infection

Characterization of bacterial iron transporter for the antioxidantability in Helicobacter pylori

The role of the transcriptional regulator, Ferric uptake regulator (Fur), in H.pylori resistance to metronidazole