Hitoshi Tsugawa

論文

血中に存在する細菌由来RNAの肝臓がん発がんに対する影響の解明(Elucidation of the effect of bacterial RNA in blood on the carcinogenesis of hepatocellular carcinoma)

Macrophage-depleted young mice are beneficial in vivo models to assess the translocation of Klebsiella pneumonia from the gastrointestinal tract to the liver in the elderly.

Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments.

血中における細菌由来RNAの検出と肝がん診断への応用(Bacteria-derived RNAs can be detected in the blood and altered in patients with hepatocellular carcinoma)

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.

Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Development of a serological assay to simultaneously identify Helicobacter suis and Helicobacter pylori infection

THE MOLECULAR REASON WHY THE GUT COMMENSAL PATHOBIONT KLEBSIELLA PNEUMONIAE DISRUPTS THE EPITHELIAL BARRIER AND TRANSLOCATES TO THE LIVER

IDENTIFICATION OF NON-HELICOBACTER BACTERIA ESSENTIAL IN GASTRIC CARCINOGENESIS IN H. PYLORI-INFECTED STOMACH

Role of gastric non-Helicobacter commensal bacteria in the development of CD44v9-positive cancer stem cells

共同研究・競争的資金等の研究課題

Molecular mechanisms of the reason that gastric cancer patients are selected from H. pylori-infected patients

Development of a two-step molecular targeted therapy to eliminate gastric cancer stem cells and progenitor cells

Role of gastric microbiota on the development of gastric cacner stem-cells in H. pylori-infected gastric mucosa

Molecular characterization of H. pylori-infected cells associated with the development of gastric cancer

Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies

Exploitation of pathogenic gastrointestinal bacteria specific molecular tageting therapy

Host cell characteristics involved in gastric carcinogenesis by H. pylori infection

Characterization of bacterial iron transporter for the antioxidantability in Helicobacter pylori

The role of the transcriptional regulator, Ferric uptake regulator (Fur), in H.pylori resistance to metronidazole