津川 仁

Hitoshi Tsugawa

  • 准教授
  • 学位:博士(薬学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

詳細情報

研究分野

  • Life sciences Bacteriology
  • Life sciences Medical biochemistry
  • Life sciences Pharmaceuticals - health and biochemistry

受賞

  • AGA Institute Poster of Distinction DDW2022
  • 第19回 日本ヘリコバクター学会 上原H. pylori賞~最優秀賞~
  • The 6th International Gastrointestinal Consensus Symposium (IGICS) Gold Medal Award
  • SFRR Asia Young Investigator Award 2011
  • 日本酸化ストレス学会 奨励賞

論文

Macrophage-depleted young mice are beneficial in vivo models to assess the translocation of Klebsiella pneumonia from the gastrointestinal tract to the liver in the elderly.

Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.

Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Development of a serological assay to simultaneously identify Helicobacter suis and Helicobacter pylori infection

THE MOLECULAR REASON WHY THE GUT COMMENSAL PATHOBIONT KLEBSIELLA PNEUMONIAE DISRUPTS THE EPITHELIAL BARRIER AND TRANSLOCATES TO THE LIVER

IDENTIFICATION OF NON-HELICOBACTER BACTERIA ESSENTIAL IN GASTRIC CARCINOGENESIS IN H. PYLORI-INFECTED STOMACH

Role of gastric non-Helicobacter commensal bacteria in the development of CD44v9-positive cancer stem cells

Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1

SHORT CHAIN FATTY ACIDS (SCFAS) DERIVED FROM GASTRIC NON-HELICOBACTER COMMENSAL BACTERIA COULD IMPART STEM-CELL PROPERTIES TO CD44V9-POSITIVE CELLS

Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes.

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.

Precision Medicine Approaches to Prevent Gastric Cancer

Neutrophil-activating protein polymorphism of Helicobacter pylori determines the host risk of dyspepsia.

Cancer stem-cell marker CD44v9-positive cells arise from Helicobacter pylori-infected CAPZA1-overexpressing cells.

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression.

書籍等出版物

  • Gastric Carcinogenesis In: Shiotani A. (eds) Gastric Cancer
  • Autophagy. -Helicobacter pylori-

講演・口頭発表等

  • The molecular reason why the gut commensal pathobiont Klebsiella pneumoniae disrupts the epithelial barrier and translocates to the liver
  • Identification of non-Helicobacter bacteria essential in gastric carcinogenesis in H. pylori-infected stomach

所属学会

  • 日本癌学会
  • 日本ヘリコバクター学会
  • 日本薬学会
  • 日本細菌学会

共同研究・競争的資金等の研究課題

Molecular mechanisms of the reason that gastric cancer patients are selected from H. pylori-infected patients

Development of a two-step molecular targeted therapy to eliminate gastric cancer stem cells and progenitor cells

Role of gastric microbiota on the development of gastric cacner stem-cells in H. pylori-infected gastric mucosa

Molecular characterization of H. pylori-infected cells associated with the development of gastric cancer

Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies

Exploitation of pathogenic gastrointestinal bacteria specific molecular tageting therapy

Host cell characteristics involved in gastric carcinogenesis by H. pylori infection

Characterization of bacterial iron transporter for the antioxidantability in Helicobacter pylori

The role of the transcriptional regulator, Ferric uptake regulator (Fur), in H.pylori resistance to metronidazole

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