Ichimura Yoshinobu

論文

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.

Development of p62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer

Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy

Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line.

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development

Activation of p62/SQSTM1-Keap1-Nuclear Factor erythroid 2-Related Factor 2 Pathway in Cancer

Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy

P62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

共同研究・競争的資金等の研究課題

Study on molecular mechanism of p62-Keap1-Nrf2 system

Phosphorylation of p62/Sqstm1 activates Nrf2 during selective autophagy

Molecular mechanisms of p62 degradation in selective autophagy

The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy

Molecular mechanisms of GRP78-involving process to repair UVC-damaged DNA