Sakai Daisuke

論文

Simultaneous translation on two rods (ST2R) improves the correction and apex 2 translocation in adolescent patients with hypokyphotic scoliosis

Augmented, virtual and mixed reality in spinal surgery: A real-world experience

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Advancing the cellular and molecular therapy for intervertebral disc disease

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro: Influence on the proliferation and proteoglycan production of HNPSV-1 cells

Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc

Differentiation of Mesenchymal Stem Cells Transplanted to a Rabbit Degenerative Disc Model

Transplantation of mesenchymal stem cells embedded in Atelocollagen® gel to the intervertebral disc: a potential therapeutic model for disc degeneration

共同研究・競争的資金等の研究課題

The investigation of the new small molecule inhibitors of IL-17A for intervertebral disc disease treatment by In Silico analysis

Basic development for reprogramming methods and translation of regenerative medicine in intervertebral disc cells

Effects of IL-17 on intervertebral disc degeneration and the investigation of the new small-molecule IL-17 inhibitor for treating degenerative discs

Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back pain

Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology

Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degeneration

Isolation and application of progenitor cells from annulus fibrosus of the intervertebral disc

Analysis of appropriate cell source for efficient annulus fibrosis regeneration

Discovering the genetics , unde rstanding progenitor cell niche and transcriptional controls to harness the endogenous regene ration potentials of the interver tebral disc

Exploratory Research Program: ANNULUS FIBROSUS REPA IR

Identifying the origin and niche environment of nucleus pulposus progenitor cells of the intervertebral disc and its therapeutic applications

Identification endogenous disc p rogenitor cells , its role in hom eostasis of disc environment an d degeneration , and its use in stem cell based regeneration