Ohtsuka Masato

論文

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss.

Revisiting the in vivo functions of coilin in mice: Requirement for snRNA modifications and formation of novel condensates in elongating spermatids.

Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition

Reduced Akr1b7 signaling drives ovarian aging and reproductive dysfunction.

Generation of mice expressing liver-specific fluorescent genes and the optimal conditions for signal detection via in vivo imaging.

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis.

The TECTB-C225Y Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice.

Channel synapse mediates neurotransmission of airway protective chemoreflexes.

Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT

In vivo functional significance of direct physical interaction between Period and Cryptochrome in mammalian circadian rhythm generation

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion

PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation.

Cross-contamination of CRISPR guides and other unrelated nucleotide sequences among commercial oligonucleotides.

Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems

Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization.

Delivering mRNAs to mouse tissues using the SEND system.

Improved Genome Editing via Oviductal Nucleic Acids Delivery (i-GONAD): Protocol Steps and Additional Notes.

Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice.

CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice.

共同研究・競争的資金等の研究課題

Understanding of MRONJ pathophysiology based on cross-species conserved regulation of tissue-resident Treg cell/macrophage crosstalk

Novel Mosaic Mouse Production Method for VLP Dynamics Analysis

Validation of the General Applicability of the SCRIPT Method for Long DNA Knock-in in Mice

Development of a Research Platform for Functional Analysis of Proteins Derived from Endogenous Viral Elements in Mammalian Genomes

Functional Analysis of Molecules Specifically Expressed in Tumor-Infiltrating Lymphocytes

Analysis of genomic DNA in aging heart

Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

Determination of chronic or intractable mechanisms induced by low bone quality with osteomacs and bone marrow derived stem cells interaction

Establishment of a next-generation impact assessment tool for low-concentration chemical exposure using THA rats

Understanding of pathophysiology and development of treatment strategy for MRONJ based on the hierarchical structure of macrophages

Understanding of pathophysiology and establishment of new treatment strategy by determining the hierarchy of macrophages in medication-related osteonecrosis of the jaw

Establishment of gene expression control system by modification of introns and its application to analysis of diabetes-related gene functions

Establishment of gene expression system by intron modification and its application for the functional analysis of diabetes-related genes