Ohtsuka Masato

論文

Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT

Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems

Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization.

Delivering mRNAs to mouse tissues using the SEND system.

Improved Genome Editing via Oviductal Nucleic Acids Delivery (i-GONAD): Protocol Steps and Additional Notes.

Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice.

CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice.

Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.

Prototype mouse models for researching SEND-based mRNA delivery and gene therapy.

Use of anti-inhibin monoclonal antibody for increasing the litter size of mouse strains and its application to i-GONAD.

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway.

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.

GONAD: A new method for germline genome editing in mice and rats.

Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools.

Indirect podocyte injury manifested in a partial podocytectomy mouse model.

Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation".

Designing and generating a mouse model: frequently asked questions.

i-GONAD: A Method for Generation of Genome Edited Animals without Ex Vivo Handling of Embryos(和訳中)

共同研究・競争的資金等の研究課題

Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy

Determination of chronic or intractable mechanisms induced by low bone quality with osteomacs and bone marrow derived stem cells interaction

Understanding of pathophysiology and establishment of new treatment strategy by determining the hierarchy of macrophages in medication-related osteonecrosis of the jaw

Establishment of gene expression system by intron modification and its application for the functional analysis of diabetes-related genes

Development of novel genome editing tool for gene therapy and its application to cancer therapy

Generation of gene modified mice using in situ genome editing system without microinjection

Molecular targeted therapy for MRONJ

Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment

The proposal of novel experimental system using original knockdown methods in mice

Development of microinjection-independent animal genome manipulation method

Role of calcium sensing receptor in Kidney Type B Intercalated Cells

Development of gene therapy for liver cirrhosis utilizing MMP13

Development of novel gene therapy strategy by insertion of artificial miRNA sequence into intronic region of endogenous gene(Fostering Joint International Research)

Screening of novel podocyte protective reagents using nephrin reporter mice

The RNA-based mechanism and function underlying molecular diversity in the nervous system

Transplantation effect of ADSC and SVF cells on ARONJ-like lesions in mice